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The hydroxyl group bound to the carbon to which R1 and R2 are attached in the compound of formula (XXIII-1) may be converted to L1-Z1-, and/or the hydroxyl group bound to the carbon to which Rx and Ry are attached may be converted to L2-Z2

Campioni M, Santini D, Tonini G, Murace R, Dragonetti E, Spugnini EP, et al

Research Resources IGF1 DES (des(1-3) IGFI) Preclinical Research Overview Quickstart Highlights Compound: IGF1 DES = des(13) IGFI (Nterminally truncated IGF1 analog) What makes it different: Much lower binding to IGF binding proteins (IGFBPs) tends to be more "bioavailable"/potent at the receptor level in experimental systems

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Another stabilizing mechanism is ligament restraint, in which the motion of the shoulder is kept within the proper range by ligaments that span the joint (See clip 4, glenhumoral capsule)

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